Why cold have a fever?

Fever is central nervous is out of control of temperature regulation, or the human body caused by exotic bacteria or virus invades the body and cause a fever.Games to generate heat, but people don't exercise, also can maintain normal temperature.Human intake of food, both fat and sugar in intracellular oxidative decomposition of mitochondrial oxidative pyruvic acid, acetyl coenzyme, ADP phosphorylation to generate ATP.ATP, or adenosine triphosphate, is biological energy currency in the body, can be used for all kinds of chemical processes in the cell.But ATP is not heat.
 
Oxidative phosphorylation is the oxidation and phosphorylation of coupling reaction.Required energy supplied by oxidative phosphorylation, formed by the oxidation of energy stored by phosphorylation.If the coupling between them was damaged, cell oxidation of carbohydrate, fat, don't make the ADP phosphorylation to generate ATP, biological oxidation is directly converted into heat energy, and the body will generate a lot of heat from the macro, presented with fever. (The Ray Ban Wayfarer Sunglasses II)
 
All damage biological oxidation and phosphorylation phase coupling effect, namely the role of inhibition of oxidative phosphorylation uncoupling effect.Uncoupler is direct send under escort coupling effect material.Common uncoupler are 2, 4-2 nitro phenol, coumarin, and so on.Uncoupling agent does not inhibit biological oxidation process of electron transfer in the mitochondria, only restrain by ADP to form ATP phosphorylation process.A cold have a fever, may be due to certain bacteria or viruses produce some uncoupler, affect oxidative phosphorylation, lead to more energy into heat energy.
 
According to research, people and animals in white adipose tissue and brown adipose tissue in the body.Brown adipose tissue within the fat oxidation using, not phosphorylation to produce ATP, but directly generate heat.Animals in the brown bear from not afraid of cold, is why by brown adipose tissue.
 
Usually we eat antipyretic analgesics antipyretic mechanism is inhibition of the hypothalamus of the temperature regulating center oxygenase (prostaglandin synthetase) activity, thus inhibiting the synthesis of prostaglandin (PG).The antipyretic analgesics only make high temperature drop to normal, the normal temperature had no effect.The antipyretic analgesics only affects the cooling process, does not affect heat production process.

 The Author: Michael
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